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Ikervis

Santen

Ikervis (1 mg/mL cyclosporine) is indicated for the treatment of severe keratitis in adult patients with dry eye disease, which has not improved despite treatment with tear substitutes. The formulation, which is supplied in single use vials, is a cationic oil-in-water emulsion of cyclosporine.

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At-a-Glance

Mechanism of Action: Cyclosporine is a cyclic polypeptide immunomodulator with immunosuppressant properties. In patients with dry eye disease, a condition that may be considered to have an inflammatory immunological mechanism, following ocular administration, cyclosporin is passively absorbed into T-lymphocyte infiltrates in the cornea and conjunctiva and inactivates calcineurin phosphatase. Cyclosporin-induced inactivation of calcineurin inhibits the dephosphorylation of the transcription factor NF-AT and prevents NF-AT translocation into the nucleus, thus blocking the release of pro-inflammatory cytokines such as IL-2.
Dosage: One drop once daily at bedtime.

Details

FDA

No

CE Mark

Yes

Active Ingredients

Cyclosporine

Application

Topical

Status

Prescription

Strength

0.1%

Company Information

Contact the company for additional information, availability, or pricing:

Santen

santenusa.com

info-usa@santeninc.com

6401 Hollis Street, Suite 125

Emeryville, CA 94608

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