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Avastin (bevacizumab) injection is a vascular endothelial growth factor directed antibody indicated for the treatment of metastatic colorectal cancer and metastatic colorectal cancer and used off-label to treat age-related macular degeneration (AMD).
Mechanism of Action: Bevacizumab binds VEGF and prevents the interaction of VEGF to its receptors (Flt-1 and KDR) on the surface of endothelial cells. The interaction of VEGF with its receptors leads to endothelial cell proliferation and new blood vessel formation in in vitro models of angiogenesis.
Yes (not for ophthalmic use)
Not specified
Bevacizumab
Intravitreal
Prescription
Not specified
Contact the company for additional information, availability, or pricing:
Genentech, Inc.
www.gene.com1 DNA Way
South San Franciso, CA 94080
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